Lensfree microscopy at CES 2020 : bedside analysis and pathology screening

CEA-Leti Will Demonstrate Next-Generation Technology that Enables Bedside Diagnosis of Disease at One-Tenth the Cost of Bulky Optical Microscopes

GRENOBLE, France – Dec. 19, 2019 – Miniaturization of sophisticated technologies has opened the door to innovative health-and-safety equipment that enables advances such as onsite, immediate evaluation of environmental risks and patient-sample analysis outside the lab. French research institute CEA-Leti’s lensfree microscope for diagnosing spinal meningitis at a fraction of the cost of bulky existing systems is the latest breakthrough in this field.

The microscope, which will be demonstrated at CES 2020, can be operated by healthcare professionals at the patient’s bedside. It provides immediate results and accurate countings of white blood cells (leukocytes) in cerebrospinal fluid, which is required to diagnose spinal meningitis, an acute inflammation of the membranes covering the brain and spinal cord.

Results in One Minute

The technology costs about one-tenth as much as an optical microscope and can image up to 10,000 microscopic biological objects at a time. Protected by 25 patents, the microscope has neither lenses nor moving parts. The analysis results are available in about one minute.

The system operates with a near-infrared light emitted by a LED that is diffracted by the biological sample being analyzed to generate a holographic pattern captured by a CMOS image sensor. Holographic reconstruction algorithms digitally recreate the image of the object on a display. Artificial intelligence software then detects, analyzes, and even classifies biological objects by tracking metrics of interest. All of these steps are automated.

CES 2020 Demo

Visitors at CEA-Leti’s booth at Eureka Park – Sands Expo – booth #50463 can observe the power of lensfree imaging to count and identify a variety of biological objects. Moving the slide under the microscope they will see the image being digitally reconstructed in real time by the microscope’s powerful algorithms. And they can watch as the embedded AI algorithms count and classify the objects being observed (eukaryotic cells, colon or lung tissues, plankton, neurons, etc.) in real time.

More details here.

About CEA-Leti (France)

Leti, a technology research institute at CEA Tech, is a global leader in miniaturization technologies enabling smart, energy-efficient and secure solutions for industry. Founded in 1967, Leti pioneers micro-& nanotechnologies, tailoring differentiating applicative solutions for global companies, SMEs and startups. Leti tackles critical challenges in healthcare, energy and digital migration. From sensors to data processing and computing solutions, Leti’s multidisciplinary teams deliver solid expertise, leveraging world-class pre-industrialization facilities. With a staff of more than 1,900, a portfolio of 2,700 patents, 91,500 sq. ft. of cleanroom space and a clear IP policy, the institute is based in Grenoble, France, and has offices in Silicon Valley and Tokyo. Leti has launched 60 startups and is a member of the Carnot Institutes network. Follow us on www.leti-cea.com and @CEA_Leti.

Follow us on www.leti.fr/en and @CEA_Leti.

CEA Tech is the technology research branch of the French Alternative Energies and Atomic Energy Commission (CEA), a key player in innovative R&D, defence & security, nuclear energy, technological research for industry and fundamental science, identified by Thomson Reuters as the second most innovative research organization in the world. CEA Tech leverages a unique innovation-driven culture and unrivalled expertise to develop and disseminate new technologies for industry, helping to create high-end products and provide a competitive edge.

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